Graphical AbstractIdentifying the properties and molecules of the intestinal microbiome may help our understanding of various diseases and therefore facilitate their treatment; from excluding pathogens to manipulation of the immune system and regulation of non-intestinal sites.

O artigo apresenta o pensamento de Dewey sustentando a tese de que formação é crescimento em função de uma efetiva relação com a vida: o humano é exigido pela vida a desenvolver-se, a crescer em direções muito diversas para então ocupar um espaço na sociedade. No intuito de gerar uma reflexão sobre o dilema da formação humana, o texto introduz outro autor, como coadjuvante, pondo em diálogo duas perspectivas implicadas pelo mesmo tema.

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In "'Yes" and "No'" (2000), Ian Rumfitt proposed bilateralism--a use-based account of the logical words, according to which the sense of a sentence is determined by the conditions under which it is asserted and denied. One of Rumfitt's key claims is that bilateralism can provide a justification of classical logic. This paper raises a techical problem for Rumfitt's proposal, one that seems to undermine the bilateralist programme.

Recently several authors have proposed proxies of welfare that equate some (as opposed to all) choices with welfare. In this paper, I first distinguish between two prominent proxies: one based oncontext-independent choicesand the other based onreason-based choices. I then propose an original proxy based on choices that individuals state they would want themselves to repeat at the time of the welfare/policy evaluation (confirmed choices). I articulate three complementary arguments that, I claim, support confirmed choices as a more reliable proxy of (...) welfare than context-independent and reason-based choices. Finally, I discuss the implications of these arguments fornudgesandboosts. (shrink)

The purpose of this article is to reflect on the changes that the implementation of artificial wombs would bring to society, the family, and the concept of motherhood and fatherhood through the lens of two recent books: Helen Sedgwick’s The Growing Season and Rebecca Ann Smith’s Baby X. Each of the two novels, set in a near future, follows the work of a scientist who develops artificial womb technology. Significantly, both women experience concerns about the technology and its long-term effects (...) that make both of them leave their laboratories and rethink the technology they invented, while considering its many ethical implications. Both novels can be seen as feminist revisionary rewritings of Aldous Huxley’s Brave New World, rejecting the vision of rows of mass-produced, anonymous babies in artificial wombs, stressing instead the closeness of the parents to their offspring. They nevertheless critically evaluate not only the many potential benefits for women of ectogenetic technology but also the possible disadvantages and pitfalls. (shrink)

Most studies investigating the relationship between cultural constructs and ethical perception have focused on individual- and societal-level values without much attention to other type of cultural constructs such as social beliefs. In addition, we need to better understand how social beliefs are linked to ethical perception and the level of analysis at which social beliefs may best predict ethical perceptions. This research contributes to the cross-cultural ethical perception literature by examining the relationship of individual-level social cynicism belief, one of five (...) universally endorsed social beliefs, together with individual social dominance orientation and the perception of unethical behavior. By means of two studies, we examine these relationships across societies that significantly differ on societal-level social cynicism belief. Using 371 business students from Russia and the U.S. in Study 1 and 268 professionals from Portugal and the U.S. in Study 2, we found that individual-level social cynicism belief was positively associated with social dominance orientation. Social dominance orientation, in turn, mediated the relationship between individual social cynicism belief and the perception of unethical behavior. Although we found significant societal-level differences in social cynicism belief in both studies, the relationships between individual-level social cynicism belief, social dominance orientation, and the perception of unethical behavior were structurally equivalent across societies in both studies, suggesting that societal-level differences did not significantly affect these relationships. Implications for cross-cultural business ethics research and practice are discussed. (shrink)

Edward Nelson published in 1986 a book defending an extreme formalist view of mathematics according to which there is an impassable barrier in the totality of exponentiation. On the positive side, Nelson embarks on a program of investigating how much mathematics can be interpreted in Raphael Robinson's theory of arithmetic Q. In the shadow of this program, some very nice logical investigations and results were produced by a number of people, not only regarding what can be interpreted in Q but (...) also what cannot be so interpreted. We explain some of these results and rely on them to discuss Nelson's position. (shrink)

The article addresses the pervasive global challenge of delayed justice, emphasizing its role as a catalyst for widespread judicial reforms. The study defines international and national court approaches to reasonable trial durations by employing systematic and comparative legal methods. It delves into essential technology courts and parties use to ensure timely proceedings, categorizing associated risks and problems. The authors advocate for the multi-door courthouse system, illustrating its efficacy in reducing delays. Furthermore, the article classifies technologies facilitating reasonable trial durations, acknowledging (...) and offering solutions for the challenges they present. This research contributes to the dynamic landscape of judicial reform, offering a holistic perspective on the multifaceted aspects of timely justice. (shrink)

Take as basic references some reflections of the philosopher Martin Heidegger about the planetary domain technique to show a shortage of time marked by the end of philosophy as metaphysics by its achievement in technical sciences. It also explains how this end of philosophy in the age of planetary domain technique can be the starting point for a new beginning of thinking, thinking beyond the limits of calculative thinking. In the concluding part of the article seeks to determine the character (...) and the task that would fit into this new way of thinking and knowing that we approach things as they are. (shrink)

Levinas’s ethics of other‐centered service has been criticized at the theoretical level for failing to offer a conception of moral agency adequate to ground its imperative and at the practical level for encouraging self‐ hatred. Levinas’s explicit resistance to the incorporation of the phrase ”as yourself“ in the Judaeo‐Christian love command might seem to validate the critics’ complaints. The author argues, on the contrary, that Levinas does offer a strong and compelling conception of moral agency and that his ethics, properly (...) understood, does not entail self‐abnegation. Levinas’s attempt to counter excessive and manipulative self‐concern and self‐inflation by insisting on the dependent and situational position of the self has been wrongly overinterpreted as an abandonment of the self and its just claims. The author seeks to establish a more balanced understanding by focusing attention on the “ethics of welcome”, on Levinas’s distinctive conception of passivity, and on the role of the “third” in all human relations. (shrink)

We formulate schemes and of the “typical” ∀∑ 1 b -sentences that are provable in T 2 1, respectively T 2 2. As an application, we reprove a recent result of Buss and Krajíček which describes witnesses for the ∀∑ 1 b -sentences provable in T 2 1 in terms of solutions to PLS-problems.

We formulate schemes and of the “typical” ∀∑ 1 b -sentences that are provable in T 2 1 , respectively T 2 2 . As an application, we reprove a recent result of Buss and Krajíček which describes witnesses for the ∀∑ 1 b -sentences provable in T 2 1 in terms of solutions to PLS-problems.

El estudio del patrimonio como fenómeno sociocultural exige prestar atención a cuáles son las representaciones que elabora y hace circular socialmente. En el caso de este artículo, el problema identificado consiste en que las reseñas históricas utilizadas en la difusión de ciudades históricas y patrimoniales pudieran estar representando negativamente a los pueblos indígenas, colaborando en la reproducción de representaciones tendenciosas. De esta manera, el objetivo de este artículo es conocer las valoraciones realizadas a los pueblos indígenas en las reseñas históricas, (...) realizándose un estudio de caso de la ciudad de La Serena (Chile). Para llevarlo a cabo, se recurre teóricamente a los Estudios Patrimoniales y a los Estudios Críticos del Discurso, optando por la arquitectura teórica de la Lingüística Sistémico-Funcional que, valiéndose del Sistema de Valoración, permite indagar sobre los efectos retóricos que construyen posicionamientos ideológicos en los discursos. Se concluye que las reseñas estudiadas poseen un posicionamiento ideológico tradicional de la historia, ya que el relato se presenta como una historia de héroes hispanos que enfrentan grandes gestas contra los indígenas, cuya participación queda descontextualizada y reducida a la destrucción de la ciudad y la oposición a los españoles. (shrink)

Cada concepción de la persona responde a un modelo antropológico determinado. Sin embargo, todas confluyen como mínimo, en dos aspectos: todas las personas son receptoras de su vida y todas comparten un anhelo último de felicidad. Pero, ¿qué implicaciones tiene esto en la búsqueda del éxito del hombre? ¿Es compatible con la vinculación al otro? ¿Qué implica ser altruista y qué rol desempeña esta conducta en la consecución del éxito? ¿Es el ser humano altruista de forma innata? De este modo, (...) se pretende analizar el fenómeno del altruismo, su origen y su sentido en la persecución del éxito de la persona desde las dimensiones biológica, psicológica y antropológica que conforman a la persona. (shrink)

Este artículo reivindica la importancia de una sociología de los transportes, un área esencial para nuestras sociedades que tradicionalmente las ciencias sociales no han atendido. Este vacío científico se ha trasladado a las investigaciones sobre la siniestrabilidad vial. En su lugar han imperado estudios sin verdadera base científica que, divulgados por los medios de comunicación, no permiten a la opinión pública visualizar la realidad del problema. Las instituciones de tráfico se limitan a establecer medidas recaudatorias y a responsabilizar a los (...) conductores. Sin embargo, un análisis detallado de los datos y un cuestionamiento razonado de los planteamientos oficiales pueden desvelarnos las auténticas causas de los accidentes. (shrink)

Este trabalho objetivou avaliar o tipo de reação à frustração e os sentimentos agressivos em presidiários. Verificou-se, também, a relação de dependência entre o tipo de delito (furto, roubo, sequestro, homicídio, latrocínio e outros) e o construto agressividade, por meio do teste de Frustração de R..

El concepto kantiano de "interés de la razón" significa en el orden teórico el impulso hacia un saber integral de las condiciones y de la voluntad de sistema, a la vez que se funde con el sentimiento de necesidad de la razón de una unidad y totalidad incondicionadas. Caracteriza así a la subjetividad finita. En el orden práctico, el interés de la razón en el cumplimiento de un orden de fines se considera la instauración de la realidad ética, mediante la (...) cual el individuo se apropia de la universalidad de la ley. Determina así el status de la subjetividad libre, aunque sensible. Este concepto permite, por tanto, una comprensión íntegra y radical de la subjetividad humana en el horizonte de una filosofía del espíritu como impulso de autorrealización. (shrink)

Can the brain become mind? If the question seems strange, aberrant even, it is perhaps due to the way the problem brain–mind is commonly presented, where what's repeatedly asked is whether the brain is or isn’t ‘mind’. Yet, if we take Deleuze and Guattari's provocation seriously, in the Conclusion of What is Philosophy?, the problem is radically recast: even if speculatively, that is, properly philosophically or conceptually, the brain, for them, involves its own becoming, both in terms of its ‘becoming-subject’ (...) and ‘becoming-mind’, as ‘Thought-brain’. I will explore references within Deleuze's philosophy in relation to the brain, namely in The Logic of Sense and his work on cinema, as I try to work out what this fantastic story (with necropolitical undertones) may in fact look like, the one where the brain not simply is but becomes, and in becoming, becomes mind…. (shrink)

Carolina Maria de Jesus, Abdias Nascimento, and Lélia Gonzalez are presented in this essay as Afro-Brazilian existentialist thinkers, whose global significance lies in their outlining philosophical interpretations of Brazil that center racial relations in the formation of the nation. By combining accounts of the lives and intellectual contributions of these thinkers, one can understand the core of each of their projects, whether in philosophical literature, sociological study of ethnic-racial relations, or philosophical anthropology. Part of a line of thought in which (...) the terms “black” and “existence” are put together, Jesus, Nascimento, and Gonzalez exemplarily proposed practices of decolonial knowledge production based on the notion that it is possible with the struggle for freedom and justice to reverse power structures that hierarchize human beings. (shrink)

RESUMO Este artigo discute a divisão do trabalho científico entre pesquisadores seniores e juniores em um centro de pesquisa brasileiro de genética humana e médica. Partindo do debate contemporâneo sobre a progressiva imbricação entre ciência e tecnologia - com progressiva fusão entre ambas, que evoca noções como a de tecnociência - é possível verificar, na subárea específica, velocidades crescentes na produção de dados, que pressionam os pesquisadores de maneiras distintas, seja pelo crescente custo das inovações tecnológicas, seja pela necessidade de (...) métodos mais complexos para a análise. Nesse contexto, analiso questões relativas à especialização do trabalho científico, à separação entre concepção e execução, e às transformações correlatas na formação de novos pesquisadores. Parte-se do pressuposto teórico-metodológico de que a atividade científica não pode ser tratada de forma homogênea, existindo configurações distintas de acordo com o espaço disciplinar, a organização institucional e a tradição científica local, entendida enquanto empreendimento historicamente enraizado e social e culturalmente contingente. ABSTRACT The article discusses the division of scientific labour among senior and junior researchers in a Brazilian research center for human and medical genetics. Starting with the contemporary debate on the progressive intertwining of science and technology - with progressive fusion of both, evoking notions such as technoscience - it is possible to verify, in this specific subarea, rising speed in data production that pressure scientists in different manners: through the rising cost of technological innovations and through the necessity for more complex methods of analysis. In this context I analyze issues concerning the specialization of scientific work, the separation between conception and execution as well as correlate changes in the formation of new researchers. The theoretical-methodological pressupposition is that scientific activity cannot be treated in a homogeneous way, and that there exist distinct configurations according to the disciplinary space, the institucional organization and local scientific tradition, understood as a historically rooted and socially and culturally contingent undertaking. (shrink)

In finite type arithmetic, the real numbers are represented by rapidly converging Cauchy sequences of rational numbers. Ulrich Kohlenbach introduced abstract types for certain structures such as metric spaces, normed spaces, Hilbert spaces, etc. With these types, the elements of the spaces are given directly, not through the mediation of a representation. However, these abstract spaces presuppose the real numbers. In this paper, we show how to set up an abstract type for the real numbers. The appropriateness of our construction (...) works in tandem with the bounded functional interpretation. (shrink)

We show that the number-theoretic functions definable in the atomic polymorphic system are exactly the extended polynomials. Two proofs of the above result are presented: one, reducing the functions’ definability problem in ${\mathbf{F}}_{\mathbf{at}}$ to definability in the simply typed lambda calculus and the other, directly adapting Helmut Schwichtenberg’s strategy for definability in $\lambda ^{\rightarrow }$ to the atomic polymorphic setting. The uniformity granted in the polymorphic system, when compared with the simply typed lambda calculus, is emphasized.

Procura-se refletir sobre as possíveis articulações entre técnica e educação no âmbito do pensamento heideggeriano. Tomando como ponto de partida os possíveis limites da analítica existencial de Ser e Tempo em questionar o fenômeno da técnica moderna, explicita-se como a questão da técnica articula-se com a questão da formação humana no Discurso de Reitorado. Caracterização da essência da técnica moderna na fase terminal da metafísica explicitando em que sentido em tal época vivemos um estado de indigência e penúria, impotentes para (...) pensar. Em um terceiro momento procura-se pensar as alternativas que se abririam à formação humana no contexto de uma época considerada pós-huma. (shrink)

This chapter contains sections titled: The Sickness unto Death Three Discourses at the Communion on Fridays further reading.

Understanding Animal Abuse and How to Intervene with Children and Young People offers a positive, compassion-based and trauma-informed approach to understanding and intervening in animal abuse. It provides an accessible cross-disciplinary synthesis of current international evidence on animal abuse, and a toolkit for professionals working with people and/or animals to help them understand, prevent, and intervene in cases of animal abuse. With contributions from experts in the field, this essential text offers ten user-friendly chapters with questions for reflection and key (...) summary points. It offers a definition of animal abuse, synthesises the latest research on children, young people and animal abuse, and explores the link between animal abuse and other forms of abuse, and legal perspectives on animal abuse. The second half of the book presents a practical toolkit for professionals, offering guidance and strategies for prevention of and intervention in cases of animal abuse. It provides multidisciplinary perspectives on interventions; from teachers' and social workers roles in detection and intervention of childhood animal abuse, to the roles of enforcement agencies and veterinarians in legal cases of adult animal abuse. Together with a final chapter proposing new directions for research, policy, and practice, this guide is for all who work with children, young people and/or animals, including psychologists, social workers, veterinarians, education professionals, and animal welfare educators. It is also key reading for those involved in legal and policy issues relating to animal welfare. (shrink)

O presente livro é o relato de um percurso que se foi traçando ao longo de anos a dialogar com Espinosa. Um dos fios que permite estabelecer o encadeamento destes escritos é o das solicitações, académicas ou outras, a que eles correspondem. É uma trama que se entretece com a disposição interna que presidiu à sua escrita - a felicidade de ler e interpretar Espinosa, o filósofo que defende a benignidade das paixões alegres e que se propõe encontrar neste mundo (...) o verdadeiro bem, susceptível de proporcionar 'a fruição eterna da suprema e contínua alegria'. (shrink)

The aim of this work is to establish a relationship between the notion of supplement, particularly that of “dangerous supplement”, and the passion for botany in Rousseau. For that, I will take as a guide the interpretations of Jacques Derrida, Alain Grosrichard and Alexandra Cook to analyze some passages from Confessions, Reveries and Letters on the botany. I have the hypothesis that botanical activity can be considered as a kind of inoffensive supplement because it evokes an image that combines sex (...) and innocence. (shrink)